2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-120576
    ML169 1222878-02-5 98%
    ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease.
    ML169
  • HY-120609
    BMS-902483 1192810-88-0 98%
    BMS-902483 is a quinuclidine-containing spirooxazolidine that is a partial agonist of the α7 nicotinic acetylcholine receptor (nAChR). BMS-902483 improves cognitive ability in preclinical rodent models..
    BMS-902483
  • HY-120641
    BMS-955829 1375751-08-8 98%
    BMS-955829 is an orally active and selective mGluR5 positive allosteric modulator with an EC50 of 2.6 nM. BMS-955829 has no intrinsic agonist activity and a low glutamate fold shift (2.4). BMS-955829 can effectively improve cognitive and executive function deficits in rodents. BMS-955829 can be used in the research of cognitive impairment diseases such as schizophrenia.
    BMS-955829
  • HY-120662
    GSK1331268 1207197-70-3 98%
    GSK1331268 is a selective, orally active agonist for mGluR2 with a pEC50 of 6.9. GSK1331268 exhibits good blood-brain barrier penetration. GSK1331268 regulates glutamate signaling, and can be used in research of neurodegenerative and neuropsychiatric diseases.
    GSK1331268
  • HY-120679
    XK469 157435-10-4 98%
    XK469 is an analog of the herbicide assure. XK469 downregulation growth arrest-specific 2 (GAS2) gene expression. XK469 has antitumor activity.
    XK469
  • HY-120682
    UH-AH 37 120382-14-1 98%
    UH-AH 37 is a muscarinic (mAChR) antagonist. UH-AH 37 exhibits a higher potency in inhibiting muscarinic responses in intestinal tissue than cardiac tissue.
    UH-AH 37
  • HY-120685
    WAY-125971 139047-48-6 98%
    WAY-125971, a propylamine analogue, is a potent and specific blocker of the rectifier potassium current (IK). WAY-125971 can be used for the study of arrhythmia.
    WAY-125971
  • HY-120686
    S-14671 135722-27-9 98%
    S-14671 is a high-affinity 5-HT1A agonist (pKi=9.3). S-14671 can be used for research on neurological diseases, such as anti-anxiety, anti-depression, etc.
    S-14671
  • HY-120688
    L-772405 177947-03-4 98%
    L-772405 is a selective 5-HT1D receptor agonist with the Ki values of 318, 29 and ＞ 1000 nM aganist guinea pig 5-HT1B receptor, guinea pig 5-HT1D receptor and rat 5-HT rransporter, respectively. L-772405 decreases the potassium-induced outflow of 5-HT with an IC50 value of 240 nM.
    L-772405
  • HY-120695
    Nafiverine 5061-22-3 98%
    Nafiverine is an antispasmodic agent. Nafiverine shows a high myolytic activity on the smooth muscles of the ileum, uterus, and coronary vessels.
    Nafiverine
  • HY-120699
    RO5488608 1337920-46-3 98%
    RO5488608 is a negative allosteric metabotropic modulator of glutamate receptor 2/3. RO5488608 inhibits LY354740 (HY-18941)-induced intracellular Ca2+ release and can be used for study of antidepressant.
    RO5488608
  • HY-120710
    DNS-8254 1821107-98-5 98%
    DNS-8254 is an oral active and brain-penetrating PDE2a inhibitor with the IC50 of 8 nM. DNS-8254 shows memory enhancing effects in a rat model.
    DNS-8254
  • HY-120727
    VU0364289 1242443-29-3 99.52%
    VU0364289 is a highly selective mGlu5 positive allosteric modulator (PAM) (binds to the MPEP (HY-14609A) site), with an EC50 of 1.6 µM. VU0364289 can reverse amphetamine-induced hyperlocomotion in a dose-dependent manner, which can be used for schizophrenia and other psychiatric research.
    VU0364289
  • HY-120769
    Pimprinine 13640-26-1
    Pimprinine is a potent monoamine oxidase inhibitor, could be isolated from fermented broths. Pimprinine has antioxidative activity and anticonvulsant activity. Pimprinine inhibits tremorine-induced tremors and analgesia in mice.
    Pimprinine
  • HY-120783
    Lu AF58801 1531592-40-1 98%
    Lu AF58801 is a potent, orally available, brain-penetrant positive allosteric modulator of α7 nicotinic acetylcholine receptors with efficacy in a novel object recognition task in mice. Lu AF58801 was shown to selectively enhance the activity of α7 nicotinic acetylcholine receptors. Lu AF58801 was able to improve cognitive function in mice treated with subchronic fluchlorothiazol (PCP).
    Lu AF58801
  • HY-120796
    MW108 hydrochloride 1454658-89-9 98%
    MW108 (MW01-11-108SRM) hydrochloride is a selective and CNS-penetrant p38αMAPK inhibitor with a Ki of 114 nM. MW108 hydrochloride ameliorates beta-amyloid induced synaptic and cognitive dysfunction.
    MW108 hydrochloride
  • HY-120810
    MCI-225 hydrate hydrochloride 476148-82-0 98%
    MCI-225 (DDP-225) hydrate hydrochloride is a selective and orally active noradrenaline (NA) reuptake inhibitor with 5-HT3 receptor antagonism. MCI-225 hydrate hydrochloride has antidepressant-like and anxiolytic-like properties. MCI-225 hydrate hydrochloride can be used for the study of anxiety disorder.
    MCI-225 hydrate hydrochloride
  • HY-120820
    LY320954 182633-59-6 98%
    LY320954 is a selective 5-HT2A receptor antagonist, with a Ki of 96 nM. LY320954 potently inhibits Ca2+ influx in the functional assay (EC50 of 35.5 nM). LY320954 inhibits 5-HT-induced paw swelling in rats, with ED50 of 4.8 mg/kg.
    LY320954
  • HY-120842
    RLH-033 157097-10-4 98%
    RLH-033 is a potent and selective ligand for the sigma 1 recognition site. RLH-033 has high affinity for sigma 1 sites labeled by [3H](+)-pentazocine with a Ki of 50 pM.
    RLH-033
  • HY-120847
    BI 186908 1453500-36-1 98%
    BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC50 of 22 nM and a Ki of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC50 of 18 nM), dog (IC50 of 23 nM) and rat (IC50 of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity.
    BI 186908
Cat. No. Product Name / Synonyms Application Reactivity